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. Author manuscript; available in PMC: 2010 Oct 5.
Published in final edited form as: Am J Hematol. 2009 Jun;84(6):349–353. doi: 10.1002/ajh.21429

Table II.

Hazard Ratio and 95% Confidence Interval for Study Endpoints by Quartile of D-Dimer, MESA, 2000–2006

D-dimer Quartiles
Outcome
Model		 ≤0.13 µg/mL 0,13 – 0.20
µg/mL		 0.21 – 0.37
µg/mL		 >0.37µg/mL
Total CVD
Events 56 51 98 102
Person-years 8516 6230 7251 6804
Crude 1.00
(Reference)		 1.25
(0.85–1.83)		 2.07
(1.49–2.87)		 2.29
(1.66–3.18)
Age, Sex and Race adjusted 1.00
(Reference)		 1.01
(0.69–1.49)		 1.41
(1.00–2.00)		 1.29
(0.90–1.85)
Age, Sex, Race and risk factor* adjusted 1.00
(Reference)		 0.92
(0.62–1.35)		 1.30
(0.92–1.84)		 1.08
(0.75–1.55)
Also adjusted for IL–6, Fibrinogen,
and CRP		 1.00
(Reference)		 0.87
(0.59–1.28)		 1.20
(0.84–1.70)		 0.95
(0.65–1.39)
Hard CHD
Events 32 36 68 71
Person-years 8575 6267 7329 6866
Crude 1.00
(Reference)		 1.55
(0.96–2.49)		 2.51
(1.65–3.82)		 2.80
(1.84–4.25)
Age, Sex and Race adjusted 1.00
(Reference)		 1.24
(0.76–2.00)		 1.69
(1.09–2.62)		 1.55
(0.98–2.44)
Age, Sex, Race and risk factor*
adjusted		 1.00
(Reference)		 1.11
(0.69–1.81)		 1.53
(0.98–2.38)		 1.27
(0.80–2.01)
Also adjusted for IL–6, Fibrinogen,
and CRP		 1.00
(Reference)		 1.05
(0.64–1.71)		 1.41
(0.90–2.21)		 1.11
(0.69–1.79)
Total Mortality
Events 21 34 58 97
Person-years 8796 6479 7533 7124
Crude 1.00
(Reference)		 2.21
(1.28–3.30)		 3.26
(1.98–5.37)		 5.79
(3.61–9.28)
Age, Sex and Race adjusted 1.00
(Reference)		 1.69
(0.97–2.92)		 1.98
(1.18–3.31)		 2.75
(1.66–4.55)
Age, Sex, Race and risk factor*
adjusted		 1.00
(Reference)		 1.62
(0.94–2.81)		 1.91
(1.14–3.21)		 2.57
(1.54–4.27)
Also adjusted for IL–6, Fibrinogen,
and CRP		 1.00
(Reference)		 1.48
(0.85–2.58)		 1.70
(1.00–2.87)		 2.14
(1.27–3.61)
*

Body mass index, systolic blood pressure, antihypertensive medications, LDL and HDL cholesterol, statin use, usual alcohol intake, smoking status, cigarette pack-years, exercise, and glycemia status.