Table III.
Hazard Ratio and 95% Confidence Interval for Study Endpoints by Quartile of Factor VIIIc, MESA, 2000–2006
| Factor VIIIc Quartiles | ||||
|---|---|---|---|---|
| Outcome Model |
≤73% | 74 – 93% | 94 – 119% | >119% |
| Total CVD | ||||
| Events | 46 | 59 | 94 | 91 |
| Person-years | 7668 | 7083 | 7029 | 7021 |
| Crude | 1.00 (Reference) |
1.08 (0.75–1.53) |
1.68 (1.22–2.32) |
1.63 (1.18–2.25) |
| Age, Sex and Race adjusted | 1.00 (Reference) |
0.97 (0.68–1.38) |
1.43 (1.04–1.99) |
1.35 (0.97–1.88) |
| Age, Sex, Race and risk factor* adjusted | 1.00 (Reference) |
0.96 (0.67–1.37) |
1.33 (0.96–1.83) |
1.17 (0.84–1.64) |
| Also adjusted for IL-6, Fibrinogen, and CRP | 1.00 (Reference) |
0.97 (0.68–1.39) |
1.25 (0.89–1.75) |
1.13 (0.80–1.75) |
| Hard CHD | ||||
| Events | 46 | 41 | 62 | 58 |
| Person-years | 7720 | 7142 | 7091 | 7086 |
| Crude | 1.00 (Reference) |
0.98 (0.64–1.49) |
1.49 (1.02–2.18) |
1.40 (0.95–2.06) |
| Age, Sex and Race adjusted | 1.00 (Reference) |
0.89 (0.58–1.36) |
1.26 (0.86–1.86) |
1.14 (0.77–1.69) |
| Age, Sex, Race and risk factor* adjusted | 1.00 (Reference) |
0.92 (0.61–1.42) |
1.21 (0.82–1.79) |
1.03 (0.69–1.53) |
| Also adjusted for IL-6, Fibrinogen, and CRP | 1.00 (Reference) |
0.93 (0.61–1.43) |
1.11 (0.74–1.66) |
0.97 (0.64–1.47) |
| Total Mortality | ||||
| Events | 30 | 39 | 64 | 77 |
| Person-years | 7907 | 7357 | 7333 | 7336 |
| Crude | 1.00 (Reference) |
1.41 (0.88–2.27) |
2.32 (1.51–3.59) |
2.80 (1.84–4.27) |
| Age, Sex and Race adjusted | 1.00 (Reference) |
1.23 (0.76–1.98) |
1.82 (1.18–2.83) |
2.00 (1.31–3.09) |
| Age, Sex, Race and risk factor* adjusted | 1.00 (Reference) |
1.25 (0.78–2.01) |
1.82 (1.18–2.83) |
1.98 (1.29–3.06) |
| Also adjusted for IL-6, Fibrinogen, and CRP | 1.00 (Reference) |
1.24 (0.76–2.02) |
1.70 (1.08–2.68) |
1.89 (1.21–2.97) |
*
Body mass index, systolic blood pressure, antihypertensive medications, LDL and HDL cholesterol, statin use, usual alcohol intake, smoking status, cigarette pack-years, exercise, and glycemia status.