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. Author manuscript; available in PMC: 2010 Oct 5.
Published in final edited form as: Am J Hematol. 2009 Jun;84(6):349–353. doi: 10.1002/ajh.21429

Table IV.

Hazard Ratio and 95% Confidence Interval for Study Endpoints by Quartile of Plasmin-Antiplasmin (PAP) Complex, MESA, 2000–2006

PAP Quartiles
Outcome
Model		 ≤3.446 nM 3.447 – 4.418
nM		 4.419 – 5.654
nM		 >5.654 nM
Total CVD
Events 62 78 75 92
Person-years 7379 7185 7206 7031
Crude 1.00
(Reference)		 1.29
(0.93–1.81)		 1.25
(0.89–1.74)		 1.57
(1.14–2.17)
Age, Sex and Race adjusted 1.00
(Reference)		 1.05
(0.75–1.47)		 0.93
(0.66–1.31)		 0.95
(0.67–1.34)
Age, Sex, Race and risk factor* adjusted 1.00
(Reference)		 1.10
(0.78–1.55)		 1.10
(0.78–1.55)		 1.06
(0.74–1.51)
Also adjusted for IL-6, Fibrinogen, and CRP 1.00
(Reference)		 1.04
(0.74–1.46)		 0.92
(0.64–1.32)		 0.83
(0.56–1.22)
Hard CHD
Events 42 44 52 69
Person-years 7428 7269 7271 7071
Crude 1.00
(Reference)		 1.08
(0.71–1.64)		 1.28
(0.85–1.92)		 1.76
(0.71–1.64)
Age, Sex and Race adjusted 1.00
(Reference)		 0.86
(0.56–1.31)		 0.93
(0.61–1.42)		 1.03
(0.68–1.56)
Age, Sex, Race and risk factor* adjusted 1.00
(Reference)		 0.88
(0.57–1.35)		 1.06
(0.69–1.62)		 1.10
(0.72–1.68)
Also adjusted for IL-6, Fibrinogen, and CRP 1.00
(Reference)		 0.84
(0.54–1.29)		 0.91
(0.59–1.42)		 0.89
(0.56–1.41)
Total Mortality
Events 24 50 52 84
Person-years 7599 7508 7463 7364
Crude 1.00
(Reference)		 2.12
(1.30–3.44)		 2.22
(1.37–3.60)		 3.66
(2.32–5.76)
Age, Sex and Race adjusted 1.00
(Reference)		 1.60
(0.98–2.62)		 1.47
(0.90–2.41)		 1.87
(1.16–3.03)
Age, Sex, Race and risk factor* adjusted 1.00
(Reference)		 1.70
(1.02 – 2.73)		 1.60
(0.97 – 2.63)		 2.00
(1.22–3.27)
Also adjusted for IL-6, Fibrinogen, and CRP 1.00
(Reference)		 1.55
(0.94–2.55)		 1.38
(0.83–2.30)		 1.55
(0.92–2.62)
*

Body mass index, systolic blood pressure, antihypertensive medications, LDL and HDL cholesterol, statin use, usual alcohol intake, smoking status, cigarette pack-years, exercise, and glycemia status.