. Author manuscript; available in PMC: 2011 Jul 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1812–1821. doi: 10.1158/1055-9965.EPI-10-0151

Table 3.

CRC tagSNP associations with nominally significant P-values

SNP	Gene	Cases	Controls	Sibships	OR^†	L95	U95	LRT P	P_act^‡
rs1677693	DHFR	1805	2878	1750	0.818	0.710	0.942	0.0041	0.0293
rs1643659	DHFR	1805	2876	1749	0.821	0.713	0.945	0.0048	0.0336
rs3788050	CBS	1796	2864	1742	0.814	0.686	0.965	0.0205	0.3137
rs4659744	MTR	1805	2878	1749	0.867	0.769	0.977	0.0225	0.1409
rs12563688	MTR	1804	2877	1748	0.871	0.773	0.982	0.0287	0.1718
rs1650723	DHFR	1803	2875	1747	0.836	0.705	0.991	0.0361	0.2040
rs12060264	MTR	1799	2862	1743	0.877	0.778	0.989	0.0381	0.2148
rs10737812	MTR	1806	2879	1750	1.137	1.008	1.282	0.0393	0.2112
rs2281649	CUBN	1806	2879	1750	1.176	1.006	1.375	0.0440	0.9591
rs719037	CBS	1804	2877	1749	0.882	0.779	0.997	0.0444	0.5264

^†

OR’s and 95% confidence limits computed using conditional logistic regression with sibship as the matching factor and controlling for age and sex.

^‡

Adjusted for multiple testing taking into account correlated tagSNPs using a modified test of Conneely and Boehnke (P_act) (28).