Table 2.

Univariate associations between baseline factors and time to change in Crohn's disease behavior in 248 patients from Olmsted County, Minnesota who did not experience an intestinal complication at the 90-day baseline.

Factors at diagnosis	Patients, n (Total, 248*)	Events, n (Total, 66)	Hazard Ratio	95% CI	p-value
Age
<16 years	32	5	1.0	Ref.
16-40 years	133	45	2.07	0.82 – 5.22	0.12
>40 years	83	16	1.29	0.47 – 3.52	0.62
Disease Location
Colon	96	7	1.0	Ref.
Terminal ileum	92	39	7.76	3.47 – 17.4	<0.001
Ileocolonic	49	15	5.63	2.29 – 13.9	<0.001
Upper GI tract	11	5	9.48	2.99 – 30.1	<0.001
Gender
Female	125	29	1.0	Ref.
Male	123	37	1.46	0.90 – 2.37	0.13
Smoking status
Non-smoker	121	26	1.0	Ref.
Current smoker	81	32	1.49	0.88 – 2.52	0.13
Ex-smoker	41	7	0.83	0.36 – 1.90	0.65
Family history of IBD
No	210	57	1.0	Ref.
Yes	33	8	0.77	0.37 – 1.61	0.49
Extra-intestinal manifestation
No	204	56	1.0	Ref.
Yes	44	10	0.80	0.41 – 1.56	0.51
Perianal disease
No	205	54	1.0	Ref
Yes	43	12	1.21	0.64 – 2.26	0.56
Any form of medication
Yes	218	60	1.0	Ref.
No	30	6	0.63	0.27 – 1.46	0.28
Corticosteroids
No	139	36	1.0	Ref.
Yes	109	30	1.30	0.80 – 2.12	0.29
5-aminosalicylates or sulfasalazine
No	72	15	1.0	Ref.
Yes	176	51	1.49	0.84 – 2.64	0.18
Azathioprine/6-mercaptopurine
No	226	62	1.0	Ref.	0.78
Yes	22	4	0.87	0.31 – 2.40
Antibiotics (>4 weeks)
No	225	60	1.0	Ref.
Yes	23	6	1.13	0.49 – 2.62	0.78

CI, confidence interval; IBD, inflammatory bowel disease.

^*One patients with <90 days follow-up from diagnosis was excluded from analysis