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. 2010 Oct 5;8(10):e1000496. doi: 10.1371/journal.pbio.1000496

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Lee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Western blot analyses of QDE-2 induction by histidine in the wild type (WT), rpa-3 knock-out (rpa-3^ko), rpa-1 knock-down (dsrpa-1), and rpa-2 knock-down (dsrpa-2) strains. Two independent rpa-3^ko strains were used. (B) Northern blot analysis of qiRNA production in the wild type (WT) and rpa-3^ko strains after histidine treatment. Histidine induces DNA damage in Neurospora. (C) qRT-PCR showing the production of DNA damage-induced aRNA from the rDNA locus after histidine treatment in wild type and rpa-3^ko strains. (D) The results of the quelling assay showing the silencing efficiency of albino-1 (al-1) gene in the wild-type, qde-3^ko, and rpa-3^ko strains. Percentage and actual numbers (shown in parenthesis) of al-1 silenced transformants are shown.