Table 2. Influenza symptoms, clinical course, and treatments of pregnant or postpartum women with 2009 A/H1N1v influenza.
ICU patients (severe) (n = 40) | Hospitalized non severe patients (moderate) (n = 111) | Outpatients (mild) (n = 164) | p value | |
Symptoms * | ||||
Hyperthermia >37.8°C | 34 (85) | 97 (89) | 131 (85) | NS |
Cough | 28 (70) | 93 (85) | 134 (86) | 0.04 |
Muscle aches | 14 (35) | 56 (51) | 94 (61) | 0.01 |
Headache | 5 (13) | 44 (40) | 61 (39) | 0.004 |
Rhinorrhea | 3 (8) | 34 (31) | 51 (33) | 0.006 |
Sore throat | 2 (5) | 14 (13) | 19 (12) | NS |
Shortness of breath | 31 (78) | 22 (20) | 14 (9) | <0.001 |
Vomiting | 6 (15) | 14 (13) | 10 (6) | NS |
Diarrhea | 1 (3) | 1 (1) | 3 (2) | NS |
Antiviral treatment | 40 (100) | 109 (98) | 150 (91) | 0.01 |
≤2 days | 18 (45) | 87 (80) | 132 (88) | |
3-5 days | 10 (25) | 16 (15) | 13 (9) | <0.001 |
>5 days | 12 (30) | 6 (6) | 5 (3) | |
Initial antibiotic therapy | 32 (80) | 75 (68) | 65 (40) | <0.001 |
Hospitalization ward | ||||
Obstetric ward | NA | 94 (85) | NA | - |
Medical ward | NA | 17 (15) | NA | - |
Specific obstetric care * , ** | 23/39 (59) | 11/109 (10) | 0/155 (0) | <0.001 |
Corticosteroids (fetal pulmonary maturation) | 10 (26) | 4 (4) | 0 (0) | <0.001 |
Tocolysis | 0 (0) | 8 (7) | 0 (0) | 0.005 |
Artificial induction of labor | 1 (3) | 1 (1) | 0 (0) | NS |
Cesarean section | 17 (44) | 1 (1) | 0 (0) | <0.001 |
Fetal consequences * , ** | 14/39 (36) | 4/109 (4) | 0/155 (0) | <0.001 |
Prematurity (<37 weeks of gestation) | 13 (33) | 2 (2) | 0 (0) | <0.001 |
Miscarriage | 0 (0) | 1 (1) | 0 (0) | NS |
Stillbirth | 1 (3) | 1 (1) | 0 (0) | NS |
Values: N (%). NA: not applicable, NS: non-significant.
*Some data were only available for 109 non-severe hospitalized patients and 155 outpatients on March 31st, 2010.
**Information about obstetric care or fetal consequences is directly related to H1N1 illness. Obstetric care and fetal consequences were registered for only the 39 ICU-hospitalized women with a prepartum onset of influenza symptoms and excluding the only post-partum case in the registry.