Table 3. Concerted regulation of expression of miRNAs in non-inflamed and inflamed CD and UC tissues.

Overexpressed miRNA
UC		CD
Non-inflamed	Inflamed	Non-inflamed	Inflamed
Cluster #7 :	Cluster #7 :	Cluster #7 :	Cluster #13 :
mir-15a	mir-7	mir-7	mir-26a
mir-26a	mir-26a	mir-26a	mir-29b
mir-29a	mir-29a	mir-30b	mir-126*
mir-29b	mir-29b	mir-30c	mir-155
mir-30c	mir-31	mir-127-3p	mir-127-3p
mir-126*	mir-126*	mir-155	mir-185
mir-127-3p	mir-127-3p	mir-223	mir-196a
mir-324-3p	mir-135b	mir-324-3p	mir-324-3p
	mir-324-3p		mir-378
		Cluster #13 :
		mir-29a
		mir-29b
		mir-126*
		mir-196a

Alterations in miRNA expression (8 UC, 8 CD patients) were clustered using a K-Means algorithm (computed on-line on the GenePattern server), independently in each IBD and for each state of the disease. Clusters that encompass several miRNAs with similarly up-regulated expression are highlighted (bold characters).