Table 2.
Number and proportion of women who developed atypia or worse (by cytology) or cervical intraepithelial neoplasia grade 2 (CIN2) or worse (by histology) during the entire follow-up period of 13.4 years in relation to human papillomavirus (HPV) type detected at baseline among cytologically normal Danish women
HPV species and type | Proportion developing atypia or worse during follow-up |
Proportion developing CIN2 or worse during follow-up |
||||||
All women with the given HPV type | Women with the given HPV type alone | Women with the given HPV type plus other high-risk HPV types except HPV16 | Women with the given HPV type plus HPV16 with or without other high-risk HPV types | All women with the given HPV type | Women with the given HPV type alone | Women with the given HPV type plus other high-risk HPV types except HPV16 | Women with the given HPV type plus HPV16 with or without other high-risk HPV types | |
N (%) | % | % | % | N (%) | % | % | % | |
Alpha 9 | ||||||||
HPV16 | 113 (38.2) | 40.7 | 36.4 | NA | 82 (27.7) | 28.5 | 27.2 | NA |
HPV31 | 77 (30.8) | 29.4 | 27.6 | 42.6 | 49 (19.6) | 15.7 | 17.1 | 31.9 |
HPV33 | 7 (34.8) | 31.9 | 31.4 | 48.4 | 36 (22.0) | 19.1 | 16.3 | 41.9 |
HPV35 | 17 (35.4) | 27.3 | 40.6 | 20.0 | 11 (22.9) | 18.2 | 28.1 | 0 |
HPV52 | 73 (29.7) | 20.3 | 30.9 | 39.1 | 39 (15.9) | 4.7 | 19.9 | 19.6 |
HPV58 | 24 (27.0) | 16.7 | 29.4 | 22.2 | 18 (20.2) | 16.7 | 22.1 | 11.1 |
Alpha 7 | ||||||||
HPV18 | 38 (32.8) | 23.1 | 37.7 | 28.6 | 24 (20.7) | 15.4 | 23.2 | 19.0 |
HPV39 | 30 (21.7) | 14.3 | 22.5 | 28.6 | 16 (11.6) | 3.6 | 10.1 | 28.6 |
HPV45 | 26 (19.3) | 14.9 | 21.3 | 23.1 | 15 (11.1) | 8.5 | 10.7 | 23.1 |
HPV59 | 11 (17.5) | 4.2 | 19.4 | 50.0 | 6 (9.5) | 0 | 6.5 | 50.0 |
HPV68 | 16 (13.7) | 3.8 | 15.6 | 21.4 | 8 (6.8) | 0 | 7.8 | 14.3 |
Alpha 6 | ||||||||
HPV53 | 21 (19.3) | 0 | 17.1 | 38.1 | 12 (11.0) | 0 | 7.9 | 28.6 |
HPV56 | 22 (18.0) | 19.4 | 13.8 | 28.6 | 9 (7.4) | 2.8 | 9.2 | 9.5 |
HPV66 | 27 (22.3) | 16.7 | 17.2 | 21.8 | 18 (14.9) | 0 | 12.6 | 25.0 |
Alpha 5 | ||||||||
HPV51 | 27 (19.3) | 17.2 | 16.7 | 29.4 | 18 (10.2) | 8.6 | 6.0 | 23.5 |
*NA = not applicable.