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. Author manuscript; available in PMC: 2010 Oct 5.
Published in final edited form as: J Immunol. 2009 Jul 1;183(1):261–269. doi: 10.4049/jimmunol.0803853

Figure 7.

Figure 7

Bcl-2 over-expression completely prevents MEK/ERK inhibition induced apoptosis in mitogen stimulated B cells. The graph shows mean % apoptosis of purified B cells as a proportion of all B cells from wt (black bars) or vav-bcl-2 transgenic mice (white bars) at 0, 24 or 48 h after stimulation with Fab2 anti-IgM antibody fragments plus IL-2, IL-4, IL-5, plus or minus the addition of the MEK1/2 inhibitor UO126 (10 µM). Data represent mean +/−SD of cells from 3 mice of each genotype analyzed in 3 independent experiments. * P<0.05, t-test.