Table II.

Summary classification of the protein families possibly associated with a salivary function in blood sucking Nematocera.

Class	Total proteins	Total families
I – Ubiquitous protein families existing outside Diptera, function known or presumed
Enzymes	170	23
Ubiquitous protease inhibitor domains	52	6
Immunity-related proteins	75	12
Mucins	106	12
OBP superfamily	186	14
Other ubiquitous families	22	5
II – Ubiquitous protein families existing outside Insects, function unknown	40	1
III– Ubiquitous insect protein families existing outside Nematocera, function unknown	31	6
IV - Protein families exclusive of blood sucking Nematocera	56	2
V - Protein families specific of mosquitoes
Found in both culicines and anophelines	83	12
Uniquely found in culicines	40	7
Uniquely found in anophelines	63	10
Uniquely found in Aedes	21	3
Uniquely found in Culex	33	1
VI - Protein families specific of black flies	123	24
VII - Protein families specific of sand flies	32	9
VIII - Protein families specific of Culicoides	41	8
IX - Salivary-orphan proteins of conserved secreted families	43	43
X - Orphan proteins of unique standing	63	63
Total	1280	261