Table I.
Clinical features, treatment, and outcome of 6 patients with primary intraocular lymphoma (PIOL)
| Pt | Age | Sex | Symptoms | Laterality | Ophthalmological findings | Treatment* | Ocular complications (latency after RT) | Response | DFS | OS | Vital status | Visual function at last follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 64 | M | Floaters | Bilateral | Vitreous cells, subretinal/choroidal infiltrates | RT (36 Gy), CT × 6, 7 d overlap | None | CR | 16 | 21 | Death due to parenchymal CNS relapse |
Right - 20/30 Left - 20/20 |
| 2 | 59 | M | Blurry vision | Right | Vitreous cells, multifocal subretinal/choroidal infiltrates | RT (36 Gy), CT × 6, 20 d overlap | Vascular retinopathy Cataract (11 months) | CR | 47 | 51 | Alive |
Right - 20/40 Left - 20/20 |
| 3 | 66 | M | Decreased visual acuity, “foggy” | Left | Vitreous cells, subretinal/choroidal and macular infiltrates | RT (36 Gy), CT × 6, 27 d overlap | Cataract Vascular retinopathy 12/16 months) | CR | 46 | 50 | Alive |
Right - 20/20 Left - 20/40 |
| 4 | 71 | F | Decreased visual acuity, “blurry” | Bilateral | Vitreous cells, multifocal subretinal/choroidal infiltrates | RT (40 Gy), CT × 6, sequential (4 d gap) | None | CR | 34 | 41 | Alive |
Right 20/20 Left 20/20 |
| 5 | 59 | M | Floaters | Bilateral | Vitreous cells | RT (36 Gy), CT × 6, sequential (5 d gap) | None | CR | 5 | 10 | Alive |
Right 20/30 Left 20/25 |
| 6 | 55 | F | Decreased visual acuity, ”flakes and floaters” | Bilateral | Vitreous cells, multifocal subretinal/choroidal infiltrates | CT × 6, RT (30 Gy), sequential (28 d gap) | Cataract Vascular retinopathy (5 months) | CR | 40 | 47 | Alive |
Right - 20/30 Left 20/25 |
Abbreviations: M=male, F=female, RT=radiation therapy (given to both eyes in all patients), CT=chemotherapy, d = day, CR=complete remission, DFS=disease-free survival, OS=overall survival, CNS=central nervous system.
*
exact treatment sequence illustrated in separate graph (Figure 1a)