. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Mol Genet Metab. 2010 Jul 23;101(2-3):115–122. doi: 10.1016/j.ymgme.2010.06.020

Table 1.

Study animals

Experimental group	Subject	Age at first IV rhIDU	Age at first IT rhIDU	Age at necropsy
IT+IV Adult	Ig	15 m	15 m	30 m
	In^*	15 m	15 m	---
	JL	14 m	14 m	29 m
	Ke	12 m	12 m	27 m

IV Adult	My	14 m	---	29 m
	Mi	14 m	---	29 m
	Mx	14 m	---	29 m
	Ms	14 m	---	29 m

IT+IV Early	I-141	23 d	112 d	18.7 m
	I-180	8 d	12 d	15.1 m
	I-196	8 d	30 d	17.3 m
	I-200	8 d	30 d	17.1 m

1.57 mg/kg IV Early	I-176	8 d	---	12.9 m
1.57 mg/kg IV Early	I-181	7 d	---	13.1 m
	I-197	8 d	---	13.0 m
	I-202	7 d	---	13.1 m

0.58 mg/kg IV Early	I-165	3 d	---	17.6 m
0.58 mg/kg IV Early	I-186	9 d	---	17.6 m
	I-189	9 d	---	17.6 m
	I-205	9 d	---	17.5 m
	I-139^*	2 d	---	---
	I-140^*	3 d	---	---

IT: intrathecal, IV: intravenous, m: month, d: day.

I-139 and I-140 died following the initial IV rhIDU administration. Subject “In” and one untreated MPS I dog died during MRI scan.