Table 2.
Spinal abnormalities on MRI in MPS I Dogs
| Cord compression |
Disk disease |
||||||
|---|---|---|---|---|---|---|---|
| Study Group | Subject | Age at study | No. levels | Severity | Signal change (no. levels) | Degeneration (no. levels) | Bony proliferation |
| 1.57 mg/kg IV Early | I-197 | 12 m | 0 | 0 | 0 | 0 | 0 |
| I-202 | 12 m | 0 | 0 | 0 | 0 | 0 | |
| I-176 | 12 m | 0 | 0 | 0 | 0 | 0 | |
| I-181 | 12 m | 0 | 0 | 0 | 0 | 0 | |
| 0.58 mg/kg IV Early | I-165 | 17 m | 0 | 0 | 0 | 0 | 0 |
| I-186 | 17 m | 1 | 1 | 0 | 2 | 0 | |
| I-189 | 17 m | 1 | 2 | 0 | 3 | 2 | |
| I-205 | 17 m | 1 | 1 | 0 | 2 | 0 | |
| IT+IV Early | I-196 | 16 m | 1 | 1 | 0 | 1 | 0 |
| I-180 | 14 m | 0 | 0 | 0 | 3 | 0 | |
| I-141 | 18 m | 1 | 2 | 0 | 3 | 0 | |
| Untreated and Pre-treated (12-19 m) | I-121 | 18 m | 1 | 3 | 1 | 1 | 0 |
| I-134 | 19 m | 1 | 3 | 0 | 2 | 1 | |
| Ig | 15 m | 1 | 2 | 0 | 1 | 0 | |
| In | 15 m | 2 | 2 | 0 | 2 | 1 | |
| JL | 14 m | 1 | 2 | --- | --- | --- | |
| Ke | 12 m | 1 | 2 | 0 | 0 | 0 | |
| My | 14 m | 1 | 2 | 0 | 2 | 2 | |
| Ms | 14 m | 3 | 2 | 0 | 4 | 2 | |
| Mi | 14 m | 3 | 3 | 0 | 4 | 3 | |
| IT+IV Adult | Ig | 30 m | 3 | 2 | 0 | 3 | 2 |
| In | 30 m | 3 | 2 | 0 | 3 | 3 | |
| JL | 29 m | 1 | 1 | 0 | 3 | 2 | |
| Ke | 27 m | 1 | 2 | 0 | 1 | 1 | |
| IV Adult | Mx | 29 m | 3 | 2 | 0 | 5 | 4 |
| My | 29 m | 3 | 2 | 0 | 6 | 2 | |
| Ms | 29 m | 3 | 2 | 0 | 6 | 0 | |
| Mi | 29 m | 3 | 2 | 2 | 6 | 5 | |
| Untreated (28 m) | I-95 | 28 m | 1 | 3 | 1 | 6 | 2 |
| I-87 | 28 m | 1 | 2 | 0 | 3 | 1 | |
IV: intravenous, IT: intrathecal, Un: Untreated (affected), m: months. Motion artifact prevented complete scoring of 14 m scan for Mx and JL. For the spinal cord compression scoring system, see Materials and Methods, section 2.3.