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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Clin Immunol. 2010 Aug 24;137(2):281–287. doi: 10.1016/j.clim.2010.07.013

Figure 5.

Figure 5

Anti-RNP antibody levels with T cell vaccination versus mock treatment. Anti 70k IgG antibodies were measured by ELISA from sera obtained prior to injection with 70k and U1-RNA (Pre-Immune), immediately prior to T cell vaccination (Pre-Treatment) and 2 months after T cell vaccination (Post-Treatment), all measured on the same ELISA plate at the same time. Mean optical density results are shown for each serum tested; group means +/− SD are also shown. For each set of sera, results are presented normalized to the same mean + 5 S.D. criterion for test positivity (dotted line). Arrows indicate results for the mice receiving T cell vaccination that continued to have nephritis despite T cell vaccination (nonresponders, as in Figure 3). The presence of high titer anti-70kD responses was not consistently present in mice with clinical nephritis. Despite its clinical benefit, T cell vaccination was not associated with a reduction in autoantibody levels. No differences between responder and nonresponder mice were noted.