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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Neurosci. 2010 Oct;13(10):1240–1248. doi: 10.1038/nn.2639

Figure 4. Sensory experience does not alter synaptic transmission or connectivity between feed–forward interneurons and stellate cells in layer 4.

Figure 4

(a) Schematic of recording configuration depicting whole–cell recordings from pairs of feed–forward interneurons and stellate cells in layer 4 barrel cortex. (b) Example traces demonstrating a connected feed–forward interneuron (action potential elicited by either a single 5 ms, +700 pA current injection, left traces, or 5 action potentials delivered at 50Hz, right traces) and stellate cell pair. The unitary postsynaptic current in the stellate cell is symmetrical around −70 mV as expected from a GABAA–receptor mediated response under the conditions of the experiment. (c) Unitary IPSC amplitudes in stellate cells in P9–11 trimmed (n=8) and untrimmed littermates (n=9). Means not significantly different (p > 0.05; two–tailed Mann–Whitney U–test). (d) Short term plasticity of feed–forward interneuron to stellate cell unitary IPSCs in P9–11 trimmed (n = 4) and untrimmed littermates (n–5). Error bars are S.E.M.