Figure 4.
mRNA expression of housekeeping genes in control and schizophrenic DLPFC. mRNA expression was measured by quantitative RT-PCR and all cases expressed as a percentage of the control mean for that gene. (A) A significant reduction in expression of SDHA, and cyclophilin (PPIA) and strong trend in GUSB mRNAs was found in schizophrenia cases compared to controls (14.4%, p=0.016; 14.9%, p=0.015; and 12.4%, p=0.052 respectively by paired t-test). (B) mRNA expression levels for all remaining housekeeping genes that did not significantly differ between diagnostic groups, including the geomean(4) (all p>0.34).