Skip to main content
. Author manuscript; available in PMC: 2010 Oct 6.
Published in final edited form as: Cell Death Differ. 2009 Sep 25;17(3):459–468. doi: 10.1038/cdd.2009.134

Figure 2. Activation of transcription factors linked to Bim regulation in the hippocampus after status epilepticus.

Figure 2

(A) Representative Western blots (n = 2 per lane) showing expression of phosphorylated (p)FoxO1 declined following seizures. Blot below shows the non-phosphorylated form and Actin as a protein loading control. (B) Graph showing semi-quantitative analysis of pFoxO1 levels in the hippocampus. (C) Representative Western blots (n = 2 per lane) showing expression of CHOP and JNK1/2/3 isoforms. Note increased CHOP and pJNK levels. (D) Graph showing semi-quantitative analysis of CHOP levels in the hippocampus. (E) Graph showing semi-quantitative analysis of pJNK1/2/3. Data are from three independent experiments. *p < 0.05 compared to control (C, 4 h). (F) Representative Western blots (n = 1 per lane) showing hippocampal Bim expression at 24 h in control and KA-treated mice given either vehicle (V) or the JNK inhibitor SP600125 (SP). Note reduced Bim induction in seizure mice treated with SP600125. Actin is included as a protein loading control.

HHS Vulnerability Disclosure