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. 2010 Aug 30;43(5):457–463. doi: 10.1111/j.1365-2184.2010.00695.x

Figure 4.

Figure 4

 Id1 up‐regulates cyclin D1 via NF‐κB in keratinocytes in vitro. (A) Id1 significantly increased luciferase activity of cyclin D1 in Rhek‐1A cells (Id1 versus vec); p65 further increased Id1‐induced action (Id1+p65 versus Id1); p65 itself significantly increased luciferase activity of cyclin D1 (p65 versus vec); and Id1+p65 significantly increased luciferase activity of cyclin D1 compared with Id1 or p65 alone (Id1+p65 versus Id1 or p65). (B) Mutation of the NF‐κB‐binding site at the promoter of cyclin D1 (CDmt) fully abrogated the Id1‐indued cyclin D1 promoter activity (Id1 versus Id1+CDmt); and CDmt itself did not increase or decrease luciferase activity (CDmt versus vec). *P < 0.05 when compared with vec in (A) or Id1 in (B).