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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2010 Nov-Dec;2(6):640–653. doi: 10.1002/wsbm.86

Table 2.

Phenotypes of Cytokine KO mice

Cytokine Receptor Fetal
Development		 Phenotype on
Blood System in
Adult		 Number of
HSC in
adult		 Ref
SCF* c-kit Normal Macrocytic anemia Decrease See text
TPO c-Mpl Normal Thrombocytopenia Decrease [128]
Ang-1 Tie-2 Lethal
(E 12.5)		 N/A See text [129]
IL-3 IL3Ra
+
Csf2rb		 Normal Lack of response
to infection in Mast
Cells		 Normal [130]
IL-6 IL6R
+
Il6st		 Normal Decrease of
T-cells in
peripheral blood		 Normal [131]
IL-11 Il11Ra
+
Il6st		 No report of KO
mice		 –
TGF-b1 TGFbr1
+
TGFbr2		 Lethal (E 10.5)
~ Normal		 Significant
increase of
monocyte &
neutrophil		 [132 , 133]
TGF-b2 TGFbr1
+
TGFbr2		 Born with
multiple
defects		 Not evaluated Not
evaluated		 [134]
TGF-b3 TGFbr1
+
TGFbr2		 Born with
abnormal lung
development
and cleft palate		 Not evaluated Not
evaluated		 [135]
*

SI mutant mice

N/A: not applicable