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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2010 Nov-Dec;2(6):640–653. doi: 10.1002/wsbm.86

Table 3.

Phenotypes of Receptor KO mice

Receptor Fetal
Development		 Phenotype on
Blood System in
Adult		 Number of HSC
in Adult		 Ref
c-Kit* Lethal
(postimplantation)
~ Normal		 Macrocytic anemia Decrease See text
c-Mpl Normal Thrombocytopenia Decrease [136]
Tie-2 Lethal
(E 10.5)		 N/A N/A [137, 138]
Il3Ra Normal Normal Normal [139]
Csf2rb Normal Acidocytopenia Normal [140]
Il6st (gp130) Lethal
(E 12.5~term)		 N/A N/A [141]
Il11Ra Normal Normal Normal [84]
Tgfbr1 Lethal
(E 10.5)		 N/A See text [142]
Tgfbr2 Lethal
(E 10.5)		 N/A N/A [143]
*

W mutant mice

N/A: not applicable