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Schematic model for PP2A regulation of Mnk/eIF4E signaling and eIF4F assembly. PP2A directly dephosphorylates Mnks and eIF4E, leading to a decrease in eIF4E phosphorylation, which enhances association of eIF4E with 4EBP-1 and subsequently inhibits eIF4F assembly. Accordingly, the expression of certain oncogenic proteins (e.g., Mcl-1 and c-Myc) is reduced in part through this mechanism.
