TABLE 3.
Virulence determinants tested in only one infection model
| Virulence determinant | Mutant phenotype in selected virulence model | Reference |
|---|---|---|
| RpoE alternative sigma factor | Does not survive in murine macrophages | 53 |
| RpoN alternative sigma factor | Does not survive in murine macrophages | 141 |
| RpoN enhancer binding protein | Decreased virulence in rat agar bead model | 68 |
| Secreted lipase | Decreased epithelial cell invasion | 116 |
| KatB catalase/ peroxidase | Decreased survival in murine macrophages | —a |
| SodC superoxide dismutase | Does not survive in murine macrophages | 76 |
| Melanin-like pigment | Does not survive in murine macrophages | 75 |
| Pbr regulator | Decreased virulence in C. elegans | 131 |
| AmiI amidase | Decrease (1 log unit) in bacterial burden in rat agar bead infections | 10 |
| Acyl carrier protein | Decreased virulence in C. elegans | 152 |
a
—, K. E. Keith and M. A. Valvano, unpublished results.