TABLE 3.
Virulence of strains following i.p. infection of C57BL/6 mice
| Expt | Challenge strain | Dosea (CFU) | No. of survivors/total no. of mice |
|---|---|---|---|
| 1b | LVS | 11 | 2/5 |
| GR13 | 13 | 3/5 | |
| GR16 | 19 | 5/5 | |
| GR17 | 32 | 5/5 | |
| 2c | LVS | 820 | 1/5 |
| GR13 | 840 | 0/5 | |
| GR16 | 1,450 | 5/5 | |
| GR17 | 1,890 | 5/5 | |
| 3 | LVS | 2,080 | 0/4 |
| GR16 (vector) | 2,270 | 4/4 | |
| GR16 (fupA/B) | 1,945 | 0/4 | |
| 4 | GR16 | 4.5 × 103 | 4/4 |
| 4.5 × 104 | 2/4 | ||
| 4.5 × 105 | 1/4 | ||
| GR17 | 8.7 × 103 | 4/4 | |
| 8.7 × 104 | 3/4 | ||
| 8.7 × 105 | 1/4 |
a
C57BL/6 mice were infected with various amounts of CFU by the i.p. route.
b
The survivors were subsequently challenged with 820 CFU of LVS by the i.p. route, and all mice survived the LVS challenge.
c
The survivors were subsequently challenged with 1.2 × 105 CFU of LVS by the i.p. route, and all except one in the GR17 mouse group survived the LVS challenge.