FIG. 4.

CD4⁺, but not CD8⁺, T cells are involved in the MOMP vaccine-induced protective response. Female C57BL/6 MOMP-vaccinated mice were either left untreated or depleted of CD4⁺ or CD8⁺ T cells prior to intravaginal infection with 100 ID₅₀ of C. muridarum. Depletion was maintained throughout the course of infection as indicated (*). (A) Course of infection, expressed as log₁₀ IFU ± standard error of the mean. (B) Percentage of culture-positive mice at each time point. The data represent duplicate determinations for groups of least 5 mice.