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. 2010 Aug 9;78(10):4421–4430. doi: 10.1128/IAI.00179-10

FIG. 4.

FIG. 4.

Higher frequencies of IL-10-producing γδ DN (CD4− CD8−) T cells are correlated with better heart function in chagasic patients. The frequency of γδ DN T cells producing IL-10 following stimulation with T. cruzi was calculated from a group of chagasic patients who had associated detailed clinical data measuring ventricular function. These measurements were the left ventricular ejection fraction (LVEF) and left ventricular diastolic diameter (LVDD). The higher the LVEF, the better the ventricular function, and the lower the LVDD, the better the ventricular function. Panel A shows Pearson's correlation plots between the frequency of IL-10-producing γδ DN T cells and LVEF or LVDD. Both plots demonstrate a highly significant correlation between higher frequencies of IL-10-producing γδ DN T cells and better ventricular function. In contrast, in panel B, no correlation is seen between IL-10-producing αβ DN T cells and measurements of ventricular function. Clinical data for a total of nine chagasic patients were used in this analysis. Statistical significance (P value) is indicated in each graph together with the r2 value.