Table 1.

Mean pharmacokinetic parameters of MTO after intravenous administration of MTO solution, uncoated liposomes, CH (0.3%) and CH (0.6%)-coated liposomes

Parameters	Solution	Uncoated liposomes	CH-coated liposomes (0.6%)	CH-coated liposomes (0.3%)
AUC (μg*mL−1* min)	162.33 ± 12.10	1193.50 ± 143.27*	1709.09 ± 203.53*,#	2738.16 ± 17.86*,#,
MRT (min)	18.73 ± 0.52	35.67 ± 4.76*	47.74 ± 0.96*,#	62.10 ± 2.15*#,
t1/2 (min)	19.33 ± 1.23	35.07 ± 5.25*	46.73 ± 2.84*,#	50.22 ± 1.04*#

Notes: Each value is the mean ± standard deviation, n = 6.

^*P < 0.05, compared with MTO solution;

^#P < 0.05, compared with uncoated liposomes;

P < 0.05, compared with CH-coated liposomes (0.6%).