Table 1.

The cytotoxicity of DNR, MNP (Fe₃O₄) with DNR, PGY1–2 with DNR, MNP (Fe₃O₄) and PGY1–2 with DNR on K562/A02 for 48 hours determined by MTT assay (mean ± SD)

Groups	IC50 of DNR (μg/mL)
DNR 14.82 ± 0.96
10 μ g/mL MNP (Fe3O4) + DNR	4.75 ± 0.59 (3.15)*
1.3 μg/mL PGY1–2 + DNR	1.08 ± 0.37 (13.7) *
10 μg/mL MNP (Fe3O4) + 1.3 μg/mL PGY1–2 + DNR	0.97 ± 0.41 (15.3) *

Notes: The values in parentheses were fold reversal (FR) calculated as follows: FR = IC_{50 DNR alone}/IC_{50 DNR + agent}.

^*P < 0.05, compared with DNR group.

Abbreviations: DNR, daunorubicin; FR, fold reversal; IC₅₀, inhibitory concentration at 50%; MNP (Fe₃O₄), magnetic nanoparticles of Fe₃O₄;rate; SD, standard deviation.