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. 2010 Jul 20;30(19):4712–4721. doi: 10.1128/MCB.00657-10

FIG. 6.

FIG. 6.

Myeloid cell-specific deletion of SIRT1 impairs systemic metabolic homeostasis on a high-fat diet. (A) Mac-SIRT1 KO mice gain more weight on a Western-style high-fat diet (n = 14 per cohort). (B) Increased leptin levels in Mac-SIRT1 KO mice following high-fat diet feeding. (C) Increased white adipose tissue in Mac-SIRT1 KO mice upon high-fat diet feeding. (D) Increased resting insulin levels in Mac-SIRT1 KO mice following a high-fat diet. (E) Oral glucose tolerance tests (1 g/kg) were carried out after 14 weeks of high-fat diet in male Mac-SIRT1 KO and control mice (n = 14 per cohort). (F) Impairment in insulin action in Mac-SIRT1 KO mice measured by insulin tolerance tests. (G) Impaired insulin signaling in tissues of Mac-SIRT1 KO mice. Total cell lysates were immunoblotted for phospho-Akt (P-Akt) or total Akt in liver, quadriceps muscle, and white adipose tissue. The data are represented as means ± SEM; *, P < 0.05, unless noted.