FIG. 12.

Model of convergence of KSHV reactivation with EBV latency in KSHV⁺/EBV⁺ B cells. Rta transactivates EBV latency promoters as if they were KSHV delayed early promoters. Rta activates EBV latency type III promoters in a background of latency type I. In accordance with previous published data suggesting a negative, reciprocal feedback between KSHV and EBV (see the text), the subsequent expression of LMP1 would inhibit Rta. Sets of cellular proteins induced by Rta and EBNA2 partially overlap.