FIG. 9.
Inactivation of the APC during HCMV infection. (A) Schematic diagram of the APCCdh1. The essential mammalian APC core subunits are shown and numbered accordingly. (B) Model illustrating the mechanisms by which the APC is disabled during HCMV infection. (I) APC5 and APC4 are targeted for degradation by the proteasome and the APC dissociates, with the TPR subunits and APC10 localizing to the cytosol while APC1 remains nuclear. (II) Cdh1 is phosphorylated, mediated by UL97, and no longer associates with the complex.