TABLE 3.
MAb neutralization of DENV-3 genotype I virusesa
| MAb | EC50 for: |
|||
|---|---|---|---|---|
| gI 16652 | gI H87 | gI UNC3044 | gI UNC3043 | |
| DENV-3-E47 | 109 | >20,000 | >20,000 | >20,000 |
| DENV-3-E49 | 4 | 113 | 2,478 | 1,229 |
| DENV-3-E50 | 24 | 16 | 1,136 | 522 |
| DENV-3-E51 | 20 | 41 | 218 | 242 |
| DENV-3-E54 | 9 | 49 | 3,121 | 2,570 |
| DENV-3-E57 | 6 | 19 | 1,013 | 1,079 |
| DENV-3-E59 | 42 | 71 | 112 | 3 |
| DENV-3-E60 | 2 | 160 | >20,000 | >20,000 |
| DENV-3-E61 | 281 | 853 | 54 | 95 |
| DENV-3-E62 | 9 | 43 | >20,000 | >20,000 |
a
FRNT analysis was performed on Vero cells with increasing concentrations of purified MAbs and 102 PFU of the indicated DENV-3 gI strain. All EC50 values are indicated in ng/ml. Values are the averages of results from three to five independent experiments performed in duplicate.