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. 2010 Aug 11;84(20):10700–10707. doi: 10.1128/JVI.01111-10

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FIG. 5. — Anti-2G12 idiotypic antibody M1G1 can be used to assess domain exchange. (A) Binding of IgG variants of 2G12 to anti-2G12 idiotypic antibody M1G1 is dependent on the conformation of 2G12. The following heavy chains were all expressed with the wild-type 2G12 light chain: wt2G12H (open dots), gl2G12H (squares), gl2G12Hdx (upright triangles), gl2G12Hdxb (inverted triangles), and gl2G12Hdxbi (diamonds). (B) Fab wt2G12dxEA (open dots; 37% domain exchanged) and corresponding purified dimeric (squares) and monomeric (triangles) Fabs.