FIG. 1.

Upregulation of soluble plasma HLA-G during progressive HIV-1 infection. (A) Surface expression of HLA-G on CD14⁺ monocytes and CD11c⁺ HLA-DR⁺ lin⁻ mDC and T cells in HIV-1 controllers (n = 10), HIV-1 progressors (n = 10), and HIV-1-negative study persons (n = 13). (B) Concentrations of soluble HLA-G in the plasma from the three patient cohorts (n = 9, 7, and 5, respectively). (C) Detection of soluble HLA-G in plasma by Western blotting. Equal amounts of plasma from two representative individuals from each of the indicated study cohorts were analyzed. (D) Intracellular levels of HLA-G in monocytes, dendritic cells, and T cells from the three study groups.