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ITC binding isotherms and corresponding raw data for 8-bp dsRNA binding to WT (A) and mutant R225A (B), K248A (C), and K251A (D) VP35 IIDs. The corresponding average KD values for WT, R225A, K248A, and K251A are 0.7, 1.0, 2.4, and 0.8 μM, respectively.
