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. Author manuscript; available in PMC: 2010 Oct 6.
Published in final edited form as: Biochem J. 2009 May 13;420(2):169–177. doi: 10.1042/BJ20081659

Fig. 2. sip1+ is an essential gene present amongst eukaryotes.

Fig. 2

A. Tetrad dissection of asci produced by the sip1::kanr/sip1+ diploid strain. Spores were grown for 3 days at 30°C on rich media YPD (left). Phase contrast micrographs of spores showing the terminal morphology of a deduced sip1-disrupted spore (right). Bar indicates 5 μm. B. Schematic of Sip1 protein domains. Sip1 protein is 1920 amino acids long and contains an amino-terminal region rich in HEAT repeats (1–1200 aa). C. Dendogram of Sip1 orthologues identified by YOGY search. The proteins are labelled with the UniProtKB nomenclature. The ClustalW alignment default parameters of MacVector 9.0 were used to create the tree. The evolutionary distance is indicated on each branch. S.p: Schizosaccharomyces pombe; D.m: Drosophila melanogaster; H.s: Homo sapiens; C.e: Caenorhabditis elegans; S.c: Saccharomyces cerevisiae.