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Cerulein-induced pain behavior. The trpv4-wt or trpv4-ko mice (A) and trpa1-wt or trpa1-ko mice (B) were treated with cerulein or vehicle control. After 12 h, pain behavior was scored. In trpv4-wt and trpa1-wt mice, cerulein increased behaviors that are characteristic of visceral pain. Pain-related behavior was diminished in trpv4-ko and trpa1-ko mice. *,#P < 0.05.
