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Effects of iron on hepcidin expression in primary human hepatocytes (A), HepG2 cells (B), and HuH7 cells (C). Hepcidin mRNA levels were significantly increased by transferrin (Tf)-Fe in primary human hepatocytes. In contrast, Tf-Fe resulted in a significant decrease in hepcidin mRNA levels in both HepG2 and HuH7 hepatoma cells. Data are means ± SE of 4–9 observations in each group. *P < 0.001; **P < 0.05 compared with untreated control cells.
