Table 2.

Incidence and severity of NEC in neonatal mouse models

Group	n	Incidence, %	Median Ileal Damage, interquartile range
ASBT WT DF	10	0.0	0.5 (0.50)
ASBT WT NEC	18	72.2a,b	2.5a,b (0.75)
ASBT KO NEC	22	27.3c	1.5 (1.00)
ASBT KO DF	10	0.0	0.5 (0.50)
BSEP WT DF	10	0.0	0.0 (0.0)
BSEP WT NEC	24	12.5d	0.5d (0.75)
BSEP OE NEC	14	71.4e	2.5e (1.50)
BSEP OE DF	10	0.0	0.5 (0.50)

Histological ileal damage was determined on a scale of 0 (normal) to 4 (necrosis). Animals with an ileal damage score ≥2 were considered to have developed NEC. ASBT, apical sodium-dependent bile acid transporter; WT, wild-type; KO, knockout; BSEP, bile salt export pump; OE, overexpressing. Incidence of NEC was determined using the χ² test. Analysis of median NEC score was determined using the Mann-Whitney test.

^aP ≤ 0.01 vs. ASBT WT DF.

^bP ≤ 0.01 vs. ASBT KO NEC.

^cP ≤ 0.05 vs. ASBT KO DF.

^dP ≤ 0.01 vs. BSEP OE NEC.

^eP ≤ 0.01 vs. BSEP OE DF.