Table 2.
Group | n | Incidence, % | Median Ileal Damage, interquartile range |
---|---|---|---|
ASBT WT DF | 10 | 0.0 | 0.5 (0.50) |
ASBT WT NEC | 18 | 72.2a,b | 2.5a,b (0.75) |
ASBT KO NEC | 22 | 27.3c | 1.5 (1.00) |
ASBT KO DF | 10 | 0.0 | 0.5 (0.50) |
BSEP WT DF | 10 | 0.0 | 0.0 (0.0) |
BSEP WT NEC | 24 | 12.5d | 0.5d (0.75) |
BSEP OE NEC | 14 | 71.4e | 2.5e (1.50) |
BSEP OE DF | 10 | 0.0 | 0.5 (0.50) |
Histological ileal damage was determined on a scale of 0 (normal) to 4 (necrosis). Animals with an ileal damage score ≥2 were considered to have developed NEC. ASBT, apical sodium-dependent bile acid transporter; WT, wild-type; KO, knockout; BSEP, bile salt export pump; OE, overexpressing. Incidence of NEC was determined using the χ2 test. Analysis of median NEC score was determined using the Mann-Whitney test.
P ≤ 0.01 vs. ASBT WT DF.
P ≤ 0.01 vs. ASBT KO NEC.
P ≤ 0.05 vs. ASBT KO DF.
P ≤ 0.01 vs. BSEP OE NEC.
P ≤ 0.01 vs. BSEP OE DF.