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The structures of Onrigin™ and its analogs used in this study (A) and the fragmentation pattern of Onrigin™ generating chloroethylating and carbamoylating species (B). 90CE and KS90 are chloroethylating and methylating agents, respectively, without the carbamoylating moiety. 101MDCE is a carbamoylating agent without the alkylating moiety. The half-lives (t1/2) of these compounds measured in phosphate buffer, pH 7.4 at 37°C are listed.
