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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Biochem Pharmacol. 2010 Jul 21;80(9):1317–1325. doi: 10.1016/j.bcp.2010.07.022

Fig. 4.

Fig. 4

AGT repair of guanine O6-methyl and guanine O6-chloroethyl lesions. Panel A, direct reversal of a guanine O6-methyl lesion by AGT. Panel B, progression of a guanine O6-chloroethyl lesion via the formation of a cyclic intermediate, N1,O6-ethanoguanine, then to a interstrand DNA G-C cross-link and AGT reparability of these lesions. Note that repair of the cyclic intermediate by AGT yields AGT tethered to guanine N-1 and that AGT does not produce repair of the DNA cross-link, because the ethylene linkage between the two DNA strands does not involve guanine O-6.