Table 2.

CMV IgG Titers and Rate of All-cause Mortality Among Subjects in the SALSA Study (N = 1,468), California, 1998–2008

	Model
	1a		2b		3b		4b		5b		6b
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
CMV antibody titers (highest quartilec)	1.59	1.28, 1.98	1.39	1.11, 1.74	1.43	1.14, 1.79	1.28	1.02, 1.61	1.36	1.09, 1.70	1.25	1.00, 1.58
Biomarkers
Comorbidity indexd	1.46	1.37, 1.56			1.39	1.30, 1.48	1.35	1.27, 1.45	1.37	1.29, 1.47	1.35	1.26, 1.44
Log(TNF)	2.47	2.03, 2.99					1.81	1.45, 2.26			1.69	1.34, 2.12
Log(IL-6)	1.73	1.50, 2.00							1.41	1.21, 1.66	1.33	1.13, 1.56
Demographics (reference)
Age	1.10	1.09, 1.12	1.10	1.08, 1.11	1.09	1.07, 1.10	1.08	1.07, 1.10	1.08	1.07, 1.10	1.08	1.07, 1.09
Gender (female)	1.29	1.05, 1.59	1.42	1.15, 1.75	1.49	1.21, 1.85	1.52	1.23, 1.88	1.50	1.21, 1.85	1.52	1.23, 1.88
Education (<high school)	1.85	1.43, 2.39	1.49	1.15, 1.93	1.53	1.18, 1.98	1.46	1.12, 1.89	1.49	1.15, 1.93	1.44	1.11, 1.87

Abbreviations: CI, confidence interval; CMV, cytomegalovirus; HR, hazard ratio; IgG, immunoglobulin G; IL-6, interleukin 6; SALSA, Sacramento Area Latino Study on Aging; TNF, tumor necrosis factor.

^aModel 1: bivariate relation with mortality.

^bModels 2–5: include variables with hazard ratio estimates.

^cReference: lower quartiles.

^dIncludes myocardial infarction, congestive heart failure, stroke, dementia, liver/renal disease, diabetes, malignancy, and leukemia or lymphoma.