Table 3.
CMV IgG Titers and Rate of CVD Mortality Among Subjects in the SALSA Study (N = 1,486), California, 1998–2008
| Model |
||||||||||||
| 1a |
2b |
3b |
4b |
5b |
6b |
|||||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| CMV IgG titers (highest quartilec) | 1.47 | 1.11, 1.95 | 1.30 | 0.97, 1.74 | 1.35 | 1.01, 1.80 | 1.17 | 0.87, 1.58 | 1.28 | 0.96, 1.71 | 1.15 | 0.86, 1.55 |
| Biomarkers | ||||||||||||
| Comorbidity indexd | 1.51 | 1.39, 1.64 | 1.44 | 1.33, 1.57 | 1.4 | 1.29, 1.52 | 1.43 | 1.31, 1.55 | 1.40 | 1.29, 1.52 | ||
| Log(TNF) | 2.66 | 2.09, 3.38 | 2.00 | 1.51, 2.64 | 1.87 | 1.40, 2.49 | ||||||
| Log(IL-6) | 1.76 | 1.47, 2.11 | 1.44 | 1.17, 1.76 | 1.33 | 1.08, 1.64 | ||||||
| Demographics (reference) | ||||||||||||
| Age | 1.11 | 1.09, 1.12 | 1.10 | 1.08, 1.12 | 1.09 | 1.07, 1.11 | 1.08 | 1.07, 1.10 | 1.08 | 1.07, 1.10 | 1.08 | 1.06, 1.10 |
| Gender (female) | 1.44 | 1.11, 1.88 | 1.57 | 1.20, 2.05 | 1.67 | 1.28, 2.19 | 1.71 | 1.30, 2.24 | 1.67 | 1.28, 2.19 | 1.71 | 1.31, 2.24 |
| Education (<high school) | 2.01 | 1.44, 2.81 | 1.62 | 1.16, 2.28 | 1.67 | 1.19, 2.34 | 1.58 | 1.13, 2.22 | 1.63 | 1.16, 2.29 | 1.57 | 1.12, 2.20 |
Abbreviations: CI, confidence interval; CMV, cytomegalovirus; CVD, cardiovascular disease; HR, hazard ratio; IgG, immunoglobulin G; IL-6, interleukin 6; SALSA, Sacramento Area Latino Study on Aging; TNF, tumor necrosis factor.
a
Model 1: bivariate relation with mortality.
b
Models 2–5: include variables with hazard ratio estimates.
c
Reference: lower quartiles.
d
Includes myocardial infarction, congestive heart failure, stroke, dementia, liver/renal disease, diabetes, malignancy, and leukemia or lymphoma.