Table I.
Single SNP results stratified by self-reported race
| Dataset | Gene or locus | rs no. | Alleles (test/reference) | Codominant model (heterozygous), OR (95% CI)a | Codominant model (homozygous), OR (95% CI)a | Additive model (per-allele), OR (95% CI)a |
| AA | CASP8 | rs1045485 | C/G | 0.96 (0.68–1.36) | 0.45 (0.05–3.74) | 0.93 (0.67–1.30) |
| rs17468277 | T/C | 0.96 (0.67–1.37) | 0.24 (0.02–3.28) | 0.92 (0.65–1.29) | ||
| FGFR2 | rs1896395 | A/C | 0.87 (0.69–1.10) | 1.69 (0.94–3.07) | 1.01 (0.83–1.23) | |
| rs11200014 | A/G | 1.00 (0.79–1.27) | 1.23 (0.71–2.11) | 1.04 (0.86–1.26) | ||
| rs2981579 | T/C | 1.39 (1.02–1.90) | 1.54 (1.12–2.13) | 1.22 (1.04–1.42) | ||
| rs1219648 | G/A | 1.13 (0.89–1.45) | 1.45 (1.05–1.99) | 1.19 (1.02–1.39) | ||
| rs2912774 | A/C | 1.05 (0.78–1.41) | 1.55 (1.13–2.13) | 1.27 (1.09–1.49) | ||
| rs2936870 | T/C | 1.05 (0.78–1.41) | 1.54 (1.12–2.11) | 1.27 (1.09–1.48) | ||
| rs2981582 | T/C | 1.30 (1.00–1.68) | 1.40 (1.02–1.91) | 1.19 (1.02–1.39) | ||
| rs2420946 | T/C | 1.02 (0.77–1.35) | 1.36 (0.99–1.86) | 1.17 (1.00–1.37) | ||
| rs2162540 | G/A | 1.19 (0.91–1.56) | 1.51 (1.11–2.06) | 1.23 (1.05–1.44) | ||
| rs3135718 | G/A | 1.11 (0.83–1.48) | 1.54 (1.14–2.10) | 1.26 (1.08–1.46) | ||
| TNRC9 3′UTR | rs8049149 | C/T | 0.93 (0.55–1.59) | 0.69 (0.04–11.25) | 0.92 (0.56–1.52) | |
| TNRC9 5′UTR | rs16951186 | C/T | 0.81 (0.63–1.03) | 1.10 (0.61–1.97) | 0.90 (0.74–1.09) | |
| TNRC9/TOX3 | rs8051542 | C/T | 1.04 (0.83–1.31) | 1.45 (0.99–2.11) | 1.14 (0.97–1.35) | |
| TNRC9/TOX3 | rs12443621 | G/A | 1.21 (0.92–1.58) | 1.35 (0.99–1.83) | 1.16 (0.99–1.35) | |
| TNRC9 5′UTR | rs3803662 | C/T | 0.97 (0.74–1.29) | 0.90 (0.66–1.23) | 0.95 (0.81–1.11) | |
| TNRC9 | rs9940048 | G/A | 1.20 (0.96–1.51) | 1.07 (0.71–1.61) | 1.10 (0.93–1.31) | |
| LSP1 | rs3817198 | C/T | 1.19 (0.93–1.52) | 0.47 (0.23–0.99) | 1.01 (0.82–1.24) | |
| H19 | rs2107425 | T/C | 1.31 (1.00–1.73) | 1.43 (1.04–1.97) | 1.20 (1.02–1.40) | |
| Msc5A1 | rs6476643 | T/G | 1.13 (0.89–1.42) | 1.21 (0.68–2.15) | 1.12 (0.92–1.36) | |
| TLR1/TLR6 | rs7696175 | T/C | 1.22 (0.88–1.71) | 4.11 (1.28–13.24) | 1.39 (1.04–1.86) | |
| MAP3K1 | rs889312 | C/A | 1.00 (0.79–1.25) | 0.84 (0.57–1.25) | 0.95 (0.80–1.13) | |
| RELN | rs17157903 | T/C | 0.87 (0.66–1.16) | 5.21 (1.48–18.29) | 1.07 (0.83–1.37) | |
| Chromosome 2p | rs4666451 | A/G | 1.03 (0.82–1.30) | 0.48 (0.28–0.81) | 0.87 (0.72–1.05) | |
| Chromosome 2q35 | rs13387042 | G/A | 1.00 (0.80–1.26) | 0.91 (0.58–1.43) | 0.98 (0.82–1.17) | |
| Chromosome 5p | rs981782 | G/T | 0.86 (0.63–1.17) | 1.10 (0.39–3.16) | 0.90 (0.68–1.19) | |
| Chromosome 5q | rs30099 | T/C | 1.26 (0.98–1.62) | 1.28 (0.59–2.74) | 1.22 (0.98–1.52) | |
| Chromosome 8q | rs13281615 | G/A | 1.14 (0.89–1.46) | 0.97 (0.70–1.34) | 1.00 (0.86–1.18) | |
| White | CASP8 | rs1045485 | C/G | 0.92 (0.75–1.13) | 0.75 (0.4–1.42) | 0.90 (0.76–1.08) |
| rs17468277 | T/C | 0.92 (0.75–1.13) | 0.75 (0.4–1.42) | 0.91 (0.76–1.08) | ||
| FGFR2 | rs1896395 | A/C | 1.51 (0.45–5.03) | 2.14 (0.78–5.92) | ||
| rs11200014 | A/G | 1.30 (1.07–1.58) | 1.63 (1.27–2.10) | 1.28 (1.13–1.45) | ||
| rs2981579 | T/C | 1.36 (1.12–1.66) | 1.71 (1.33–2.19) | 1.31 (1.16–1.48) | ||
| rs1219648 | G/A | 1.35 (1.11–1.63) | 1.65 (1.28–2.12) | 1.30 (1.15–1.46) | ||
| rs2912774 | A/C | 1.39 (1.14–1.68) | 1.63 (1.27–2.09) | 1.29 (1.14–1.46) | ||
| rs2936870 | T/C | 1.38 (1.14–1.67) | 1.64 (1.27–2.11) | 1.30 (1.15–1.46) | ||
| rs2981582 | T/C | 1.37 (1.13–1.66) | 1.62 (1.26–2.09) | 1.29 (1.14–1.46) | ||
| rs2420946 | T/C | 1.38 (1.14–1.67) | 1.62 (1.25–2.08) | 1.29 (1.14–1.46) | ||
| rs2162540 | G/A | 1.35 (1.12–1.64) | 1.63 (1.26–2.10) | 1.29 (1.14–1.46) | ||
| rs3135718 | G/A | 1.40 (1.15–1.69) | 1.64 (1.28–2.12) | 1.30 (1.15–1.47) | ||
| TNRC9 3′UTR | rs8049149 | C/T | 0.84 (0.10–6.81) | 0.84 (0.10–6.81) | ||
| TNRC9 5′ UTR | rs16951186 | C/T | 1.14 (0.63–2.04) | 1.14 (0.63–2.04) | ||
| TNRC9/TOX3 | rs8051542 | C/T | 0.92 (0.76–1.12) | 0.26 (0.98–1.61) | 1.10 (0.97–1.24) | |
| TNRC9/TOX3 | rs12443621 | G/A | 0.75 (0.61–0.93) | 0.74 (0.58–0.95) | 0.87 (0.77–0.98) | |
| TNRC9 5′ UTR | rs3803662 | C/T | 1.20 (1.00–1.44) | 1.64 (1.20–2.23) | 1.25 (1.09–1.42) | |
| TNRC9 | rs9940048 | G/A | 1.07 (0.89–1.28) | 1.01 (0.70–1.48) | 1.04 (0.90–1.20) | |
| LSP1 | rs3817198 | C/T | 1.04 (0.87–1.25) | 1.27 (0.94–1.71) | 1.07 (0.96–1.25) | |
| H19 | rs2107425 | T/C | 0.90 (0.75–1.07) | 0.70 (0.52–0.96) | 0.86 (0.75–0.98) | |
| Msc5A1 | rs6476643 | T/G | 1.07 (0.89–1.28) | 0.88 (0.61–1.25) | 1.00 (0.87–1.15) | |
| TLR1/TLR6 | rs7696175 | T/C | 0.96 (0.78–1.16) | 1.20 (0.93–1.53) | 1.08 (0.95–1.22) | |
| MAP3K1 | rs889312 | C/A | 1.06 (0.88–1.27) | 1.57 (1.16–2.13) | 1.18 (1.03–1.34) | |
| RELN | rs17157903 | T/C | 0.86 (0.70–1.06) | 0.79 (0.46–1.38) | 0.87 (0.73–1.03) | |
| Chromosome 2p | rs4666451 | A/G | 1.05 (0.87–1.27) | 0.96 (0.74–1.24) | 0.99 (0.88–1.13) | |
| Chromosome 2q35 | rs13387042 | G/A | 0.92 (0.75–1.12) | 0.88 (0.68–1.12) | 0.93 (0.83–1.06) | |
| Chromosome 5p | rs981782 | G/T | 0.96 (0.78–1.18) | 1.05 (0.82–1.35) | 1.02 (0.90–1.15) | |
| Chromosome 5q | rs30099 | T/C | 1.07 (0.85–1.34) | 0.79 (0.33–1.89) | 1.03 (0.84–1.26) | |
| Chromosome 8q | rs13281615 | G/A | 1.17 (0.97–1.43) | 1.23 (0.95–1.58) | 1.12 (0.99–1.26) |
a
Adjusted for age, European ancestry and offset term.