Table II.
Single SNP analysis stratified by age at diagnosis
| Dataset | Gene or locus | rs no. | Alleles (test/reference) | Codominant model (heterozygous), OR (95% CI)a | Codominant model (homozygous), OR (95% CI)a | Additive model (per-allele), OR (95% CI)a |
| Age ≥ 50 | CASP8 | rs1045485 | C/G | 0.80 (0.62–1.03) | 0.86 (0.35–2.13) | 0.83 (0.66–1.03) |
| rs17468277 | T/C | 0.79 (0.62–1.02) | 0.82 (0.32–2.06) | 0.82 (0.65–1.02) | ||
| FGFR2 | rs1896395 | A/C | 0.97 (0.71–1.34) | 1.76 (0.81–3.83) | 1.10 (0.85–1.43) | |
| rs11200014 | A/G | 1.43 (1.16–1.77) | 1.65 (1.20–2.26) | 1.32 (1.14–1.53) | ||
| rs2981579 | T/C | 1.66 (1.31–2.10) | 1.90 (1.44–2.49) | 1.38 (1.20–1.58) | ||
| rs1219648 | G/A | 1.46 (1.18–1.80) | 1.78 (1.35–2.35) | 1.35 (1.18–1.55) | ||
| rs2912774 | A/C | 1.43 (1.14–1.79) | 1.95 (1.49–2.56) | 1.40 (1.22–1.60) | ||
| rs2936870 | T/C | 1.45 (1.15–1.82) | 1.94 (1.48–2.55) | 1.40 (1.22–1.60) | ||
| rs2981582 | T/C | 1.52 (1.23–1.89) | 1.77 (1.35–2.34) | 1.36 (1.18–1.55) | ||
| rs2420946 | T/C | 1.47 (1.18–1.83) | 1.81 (1.38–2.37) | 1.35 (1.18–1.55) | ||
| rs2162540 | G/A | 1.49 (1.20–1.86) | 1.89 (1.44–2.48) | 1.39 (1.21–1.59) | ||
| rs3135718 | G/A | 1.53 (1.22–1.92) | 1.96 (1.50–2.56) | 1.41 (1.23–1.61) | ||
| TNRC9 3′ UTR | rs8049149 | C/T | 0.81 (0.37–1.79) | 0.98 (0.47–2.06) | ||
| TNRC9 5′ UTR | rs16951186 | C/T | 0.90 (0.66–1.23) | 1.11 (0.50–2.47) | 0.93 (0.72–1.21) | |
| TNRC9/TOX3 | rs8051542 | C/T | 0.80 (0.65–0.99) | 1.58 (1.18–2.11) | 1.14 (0.99–1.31) | |
| TNRC9/TOX3 | rs12443621 | G/A | 0.98 (0.77–1.23) | 1.00 (0.77–1.30) | 1.02 (0.89–1.16) | |
| TNRC9 5′UTR | rs3803662 | C/T | 1.05 (0.85–1.30) | 1.06 (0.78–1.42) | 1.03 (0.89–1.19) | |
| TNRC9 | rs9940048 | G/A | 1.18 (0.97–1.43) | 1.08 (0.73–1.60) | 1.10 (0.94–1.28) | |
| LSP1 | rs3817198 | C/T | 0.98 (0.80–1.21) | 1.00 (0.68–1.46) | 1.00 (0.85–1.16) | |
| H19 | rs2107425 | T/C | 1.05 (0.85–1.29) | 0.82 (0.61–1.11) | 0.95 (0.82–1.09) | |
| Msc5A1 | rs6476643 | T/G | 1.23 (1.01–1.50) | 0.93 (0.61–1.40) | 1.07 (0.91–1.25) | |
| TLR1/TLR6 | rs7696175 | T/C | 0.95 (0.75–1.20) | 0.88 (0.63–1.23) | 0.96 (0.82–1.12) | |
| MAP3K1 | rs889312 | C/A | 1.13 (0.92–1.38) | 1.05 (0.75–1.47) | 1.06 (0.92–1.22) | |
| RELN | rs17157903 | T/C | 0.87 (0.69–1.10) | 1.40 (0.70–2.78) | 0.94 (0.77–1.15) | |
| Chromosome 2p | rs4666451 | A/G | 0.98 (0.80–1.21) | 0.81 (0.59–1.12) | 0.93 (0.80–1.07) | |
| Chromosome 2q35 | rs13387042 | G/A | 0.97 (0.79–1.02) | 0.85 (0.63–1.14) | 0.93 (0.81–1.07) | |
| Chromosome 5p | rs981782 | G/T | 0.96 (0.76–1.22) | 1.20 (0.86–1.67) | 1.07 (0.91–1.25) | |
| Chromosome 5q | rs30099 | T/C | 1.27 (1.00–1.62) | 0.99 (0.48–2.05) | 1.18 (0.96–1.46) | |
| Chromosome 8q | rs13281615 | G/A | 1.29 (1.04–1.59) | 1.28 (0.97–1.70) | 1.15 (1.01–1.32) | |
| Age < 50 | CASP8 | rs1045485 | C/G | 1.10 (0.85–1.42) | 0.64 (0.27–1.49) | 1.01 (0.81–1.27) |
| rs17468277 | T/C | 1.10 (0.85–1.43) | 0.64 (0.27–1.49) | 1.01 (0.81–1.27) | ||
| FGFR2 | rs1896395 | A/C | 0.81 (0.58–1.13) | 2.07 (0.84–5.11) | 0.99 (0.74–1.31) | |
| rs11200014 | A/G | 0.96 (0.77–1.19) | 1.35 (0.98–1.86) | 1.10 (0.95–1.28) | ||
| rs2981579 | T/C | 1.16 (0.91–1.47) | 1.39 (1.05–1.84) | 1.18 (1.03–1.36) | ||
| rs1219648 | G/A | 1.10 (0.88–1.38) | 1.37 (1.03–1.84) | 1.16 (1.01–1.34) | ||
| rs2912774 | A/C | 1.16 (0.92–1.46) | 1.40 (1.06–1.86) | 1.18 (1.03–1.36) | ||
| rs2936870 | T/C | 1.13 (0.89–1.42) | 1.42 (1.07–1.89) | 1.19 (1.03–1.37) | ||
| rs2981582 | T/C | 1.21 (0.97–1.51) | 1.30 (0.98–1.74) | 1.15 (1.00–1.33) | ||
| rs2420946 | T/C | 1.08 (0.86–1.36) | 1.32 (0.99–1.75) | 1.14 (0.99–1.32) | ||
| rs2162540 | G/A | 1.14 (0.91–1.43) | 1.34 (1.01–1.78) | 1.16 (1.00–1.33) | ||
| rs3135718 | G/A | 1.12 (0.89–1.41) | 1.39 (1.05–1.84) | 1.18 (1.02–1.35) | ||
| TNRC9 3′ UTR | rs8049149 | C/T | 1.02 (0.51–2.04) | 0.87 (0.45–1.65) | ||
| TNRC9 5′ UTR | rs16951186 | C/T | 0.81 (0.58–1.13) | 1.21 (0.51–2.90) | 0.94 (0.72–1.24) | |
| TNRC9/TOX3 | rs8051542 | C/T | 1.16 (0.93–1.44) | 1.14 (0.84–1.53) | 1.08 (0.93–1.24) | |
| TNRC9/TOX3 | rs12443621 | G/A | 0.83 (0.65–1.05) | 0.85 (0.64–1.12) | 0.92 (0.80–1.06) | |
| TNRC9 5′UTR | rs3803662 | C/T | 1.26 (1.01–1.57) | 1.41 (1.05–1.91) | 1.20 (1.04–1.39) | |
| TNRC9 | rs9940048 | G/A | 1.07 (0.87–1.32) | 1.04 (0.70–1.54) | 1.02 (0.87–1.19) | |
| LSP1 | rs3817198 | C/T | 1.17 (0.95–1.45) | 1.27 (0.86–1.88) | 1.14 (0.98–1.33) | |
| H19 | rs2107425 | T/C | 0.94 (0.75–1.17) | 1.10 (0.81–1.51) | 1.02 (0.88–1.18) | |
| Msc5A1 | rs6476643 | T/G | 0.99 (0.80–1.22) | 1.06 (0.67–1.66) | 1.02 (0.86–1.20) | |
| TLR1/TLR6 | rs7696175 | T/C | 1.12 (0.88–1.44) | 1.84 (1.32–2.58) | 1.28 (1.09–1.49) | |
| MAP3K1 | rs889312 | C/A | 0.94 (0.76–1.15) | 1.50 (1.05–2.15) | 1.12 (0.94–1.30) | |
| RELN | rs17157903 | T/C | 0.84 (0.66–1.08) | 1.15 (0.58–2.30) | 0.91 (0.74–1.11) | |
| Chromosome 2p | rs4666451 | A/G | 1.08 (0.87–1.34) | 0.89 (0.64–1.24) | 0.99 (0.85–1.14) | |
| Chromosome 2q35 | rs13387042 | G/A | 0.94 (0.75–1.17) | 0.91 (0.67–1.23) | 0.95 (0.82–1.10) | |
| Chromosome 5p | rs981782 | G/T | 0.88 (0.68–1.12) | 0.91 (0.65–1.28) | 0.94 (0.80–1.11) | |
| Chromosome 5q | rs30099 | T/C | 1.06 (0.83–1.35) | 1.05 (0.40–2.75) | 1.05 (0.84–1.31) | |
| Chromosome 8q | rs13281615 | G/A | 1.06 (0.84–1.32) | 0.94 (0.74–1.25) | 1.00 (0.87–1.15) |
a
Adjusted for age, race, European ancestry and offset term.