Table IV.

Haplotype results stratified by age at diagnosis

Dataset	Gene	Haplotype	Haplotype frequency (%)	OR (95% CI)a	P-value (t-statistic)a
Age ≥ 50	CASP8b	GC	89.7	Reference	—
		CT	10.0	0.79 (0.64–0.98)	0.03
	FGFR2c	GCAC	48.3	Reference	—
		ATGT	30.2	1.37 (1.18–1.58)	2.51E-05
		GTGT	9.0	1.39 (1.08–1.80)	0.01
		GTAC	2.9	1.25 (0.83–1.87)	0.29
		GTAT	3.9	1.29 (0.90–1.86)	0.16
		ATAC	2.2	1.55 (0.98–2.44)	0.06
		GCAT	1.0	0.85 (0.43–1.68)	0.63
		ATGC	1.3	1.35 (0.75–2.45)	0.32
	TNRC9d	AC	45.9	Reference	—
		AT	5.6	0.96 (0.70–1.33)	0.82
		GC	16.6	0.95 (0.79–1.15)	0.61
		GT	31.8	1.03 (0.89–1.19)	0.69
Age < 50	CASP8b	GC	89.5	Reference	—
		CT	10.3	1.04 (0.84–1.29)	0.74
	FGFR2c	GCAC	48.0	Reference	—
		ATGT	31.2	1.14 (0.98–1.32)	0.10
		GTGT	8.8	1.35 (1.02–1.78)	0.03
		GTAC	3.1	0.99 (0.64–1.53)	0.95
		GTAT	3.0	1.30 (0.85–1.99)	0.22
		ATAC	2.4	1.01 (0.64–1.59)	0.98
		GCAT	1.1	0.61 (0.31–1.22)	0.16
		GCGT	1.2	0.80 (0.43–1.48)	0.47
	TNRC9d	AC	44.9	Reference	—
		AT	5.5	1.10 (0.79–1.54)	0.58
		GC	16.0	0.97 (0.79–1.19)	0.76
		GT	33.5	1.17 (1.01–1.36)	0.04

^aAdjusted for age, race, European ancestry and offset term.

^bCASP8 SNPs are rs1045485 and rs17468277 in relative nucleotide location order.

^cFGFR2 SNPs are rs11200014, rs2981579, rs1219648 and rs2420946 in relative nucleotide location order.

^dTNRC9 SNPs are rs12443621 and rs3803662 in relative nucleotide location order.