Table 2.
Isoflavonoid correlations and equation parameters for converting plasma, overnight urine, and spot urine values
| ICC* | OU vs. PL | SU vs. PL | OU vs. SU | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| r† (MAD°) | a‡ (95% CI) | b‡ (95% CI) | rtest¶ | r† (MAD°) | a‡ (95% CI) | b‡ (95% CI) | rtest¶ | r† (MAD°) | a§ (95% CI) | b§ (95% CI) | rtest¶ | ||
| DE | 0.95 | 0.83 (16.4) | 9.33 (8.62–10.10) | 1.08 (1.04–1.12) | 0.87 | 0.83 (17.7) | 11.43 (10.56–12.37) | 1.15 (1.11–1.20) | 0.78 | 0.93 (0.81) | 0.97 (0.91–1.02) | 0.82 (0.79–0.84) | 0.84 |
| GE | 0.97 | 0.91 (27.8) | 9.49 (8.94–10.08) | 1.51 (1.47–1.56) | 0.93 | 0.89 (4.4) | 12.14 (11.33–13.03) | 1.54 (1.49–1.60) | 0.82 | 0.92 (0.39) | 0.93 (0.89–0.97) | 0.83 (0.80–0.85) | 0.81 |
| GLYE | 0.86 | 0.60 (2.6) | 4.85 (4.67–5.05) | 0.97 (0.90.–1.05) | 0.66 | 0.61 (2.0) | 6.44 (6.25–6.64) | 1.11 (1.03–1.20) | 0.67 | 0.82 (0.11) | 0.65 (0.62–0.67) | 0.79 (0.76–0.82) | 0.70 |
| EQ | 0.94 | 0.80 (4.4) | 5.97 (5.66–6.30) | 1.21 (1.16–1.26) | 0.86 | 0.79 (4.4) | 5.62 (5.29–5.96) | 1.16 (1.11–1.22) | 0.85 | 0.94 (0.04) | 1.02 (0.99–1.05) | 0.94 (0.92–0.97) | 0.93 |
| DMA | 0.95 | 0.83 (6.3) | 5.96 (5.53–6.42) | 1.31 (1.26–1.36) | 0.86 | 0.81 (8.1) | 6.63 (6.17–7.12) | 1.25 (1.20–1.31) | 0.82 | 0.93 (0.36) | 1.12 (1.07–1.17) | 0.88 (0.85–0.90) | 0.90 |
| DHDE | 0.93 | 0.76 (3.2) | 5.81 (5.41–6.23) | 1.07 (1.01–1.12) | 0.82 | 0.80 (3.5) | 5.81 (5.42–6.23) | 1.12 (1.07–1.17) | 0.78 | 0.92 (0.23) | 1.03 (0.98–1.08) | 0.85 (0.82–0.87) | 0.85 |
| DHGE | 0.93 | 0.78 (0.8) | 2.6 (2.47–2.73) | 1.26 (1.20–1.31) | 0.79 | 0.79 (1.0) | 2.69 (2.56–2.84) | 1.24 (1.18–1.30) | 0.77 | 0.90 (0.05) | 0.92 (0.88–0.95) | 0.85 (0.82–0.88) | 0.77 |
Based on log- transformed data comparing between subjects ; except for rtest all values are based on 87% of randomly selected data (1459 OU-PL, 1536 SU-PL, 1444 OU-SU pairs)
Intraclass correlation as reliability estimate across OU, SU, and PL (between subjects)
Pearson correlation coefficients between OU, SU, and PL pairs (between subjects)
Parameters are for the equation to convert urine values (nmol/mg) into plasma levels (nM) using 87% of available data; plasma = a * (urine)b
rtest = Pearson correlation coefficients of residual 13% of available data between predicted plasma levels obtained from converting urine values with developed equations and measured plasma levels
Parameters are for the equation to interconvert urine values (nmol/mg) using 87% of available data; spot urine = a * (overnight urine)b
Median absolute difference (OU-PL and SU-PL in nM; OU-SU in nmol/mg) of predicted versus measured IFL levels
Abbreviations: DE = daidzein, GE = genistein, GLYE = glycitein, EQ = equol, DMA = O-desmethylangolensin, DHDE = dihydrodaidzein, DHGE = dihydrogenistein ; OU = overnight urine (nmol/mg creatinine), PL = plasma (nM), SU = spot urine (nmol/mg creatinine); CI=confidence interval