Figure 3.
This figure illustrates the mean ± SEM Ketamine (K) levels for the R (solid blue line and diamond symbols) ) and S enantiomers (solid red line and square symbols). Norketamine levels are similarly illustrated with a solid green line and triangles and a solid purple line and x symbols. The X axis shows the baseline and infusion period with the corresponding Ketamine and Norketamine blood levels during the 4-5 hour incremental dosing period. The subjects’ pain relief scores are illustrated by white circles in the figure to provide a reference to the achieved level of analgesia. Blood levels for both Ketamine and Norketamine were significantly (p<0.05) increased from baseline at all time points with a corresponding increase in pain relief.