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. 2010 Aug 5;172(5):578–590. doi: 10.1093/aje/kwq175

Table 6.

Association Between Ever Use of Aspirin and Prostate Cancer Among Caucasians, According to Genotypes of Selected PTGS1 and PTGS2 Gene Variants, in a Population-based Case-Control Study in King County, Washington, 2002–2005

Exposure MAFa MAFb Cases, no. Controls, no. Odds Ratioc 95% CI Pinteraction
Ever use of aspirin
    Neverd 362 314 1.00 Referent
    Ever 349 404 0.75 0.61, 0.92
PTGS1
    rs1236913 (Trp8Arg) 0.071 0.075 0.52
        CC 296 340 0.74 0.58, 0.94
        TT + TC 48 63 0.56 0.29, 1.08
    rs3842787 (Pro17Leu) 0.061 0.068 0.36
        CC 303 353 0.67 0.53, 0.85
        TT + TC 39 49 1.08 0.53, 2.24
    rs5789 (Leu237Met)e 0.028 0.030 0.43
        CC 322 373 0.71 0.56, 0.89
        CA 14 21 0.71 0.24, 2.12
PTGS2
    rs6685280 0.227 0.203 0.66
        AA 204 242 0.75 0.56, 1.00
        CC + CA 126 139 0.67 0.46, 0.97
    rs964570 0.083 0.070 0.69
        GG 293 347 0.69 0.55, 0.88
        AA + GA 52 56 0.73 0.39, 1.37
    rs6425043e 0.038 0.031 0.45
        AA 319 379 0.70 0.56, 0.88
        AG 26 22 0.78 0.31, 1.94
    rs1119231 0.151 0.130 0.56
        GG 256 303 0.73 0.56, 0.95
        AA + AG 85 94 0.64 0.42, 0.99
    rs12042763 0.260 0.254 0.02
        GG 177 233 0.60 0.44, 0.81
        TT + TG 165 169 0.86 0.61, 1.20
    rs689462 0.026 0.029 0.13
        AA 330 376 0.73 0.58, 0.91
        CC + CA 9 23 0.20 0.05, 0.75
    rs689466 0.179 0.192 0.32
        AA 237 276 0.73 0.56, 0.96
        GG + GA 107 127 0.66 0.44, 0.98
    rs2745557 0.181 0.207 0.53
        GG 225 251 0.63 0.48, 0.83
        AA + AG 110 145 0.80 0.54, 1.19
    rs4648261e 0.024 0.027 0.09
        GG 329 374 0.75 0.59, 0.94
        GA 14 29 0.17 0.05, 0.57
    rs2066826 0.139 0.129 0.51
        GG 254 307 0.72 0.55, 0.93
        AA + AG 81 92 0.63 0.40, 0.98
    rs5275 0.348 0.330 0.10
        TT 150 170 0.87 0.62, 1.22
        CC + CT 195 232 0.59 0.44, 0.80
    rs689470 0.025 0.028 0.07
        CC 329 376 0.73 0.58, 0.91
        TT + TC 8 23 0.13 0.03, 0.55

Abbreviations: CI, confidence interval; MAF, minor allele frequency.

a

For Caucasian cases.

b

For Caucasian controls.

c

Adjusted for age at reference date and prostate cancer screening history within the 5 years prior to reference date.

d

Nonusers of aspirin are the reference group in each model (stratified by genotype), but totals vary according to the number of men with genotype data available.

e

No men were homozygous for the minor allele.